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目的:观察脑通胶囊对血管性痴呆模型大鼠学习、记忆以及海马CA1区突触可塑性的影响。方法:采用改良的四血管法制备VD模型,Morris水迷宫测定大鼠学习、记忆能力,电镜观察海马CA1区突触超微结构的变化。结果:与模型组比较,脑通胶囊大、中剂量组逃避潜伏期缩短,穿越原平台次数增多(P<0.05~P<0.01)。模型组突触前、后膜模糊,突触间隙变窄,突触后致密带密度低,突触活性带较短,突触囊泡不清。假手术组突触结构形态正常。大剂量组、中剂量组突触结构形态接近于假手术组。结论:脑通胶囊可减轻海马CA1区突触损伤,从而改善VD大鼠学习、记忆能力。
Objective: To observe the effects of Naotong capsule on learning and memory, synaptic plasticity in hippocampal CA1 area of vascular dementia model rats. Methods: VD model was prepared by modified four-vessel method. Morris water maze was used to study the learning and memory abilities of rats. The ultrastructure of synaptic ultrastructure in CA1 hippocampus was observed by electron microscope. Results: Compared with the model group, Nao-Tung Capsule had the shortened escape latency and the number of passing through the original platform (P <0.05 ~ P <0.01). The anterior and posterior membrane of the model group were fuzzy, the synaptic cleft narrowed, the density of the postsynaptic dense zone was low, the synaptic active zone was short and the synaptic vesicles were unclear. The sham operation group had normal synapse structure. The synaptic structure of high-dose group and middle-dose group was similar to sham operation group. Conclusion: Naotong capsule can reduce the synaptic damage in hippocampal CA1 area and improve learning and memory ability of VD rats.