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硝普盐的药物动力学:(1)吸收:Page 等给16例高血压患者口服6周至2年的硝普钠,30～60mg(qid),轻度降压作用在几周后才出现。血压下降值和血浆中的硫氰酸盐浓度相应。硝普钠从胃肠道吸收的量并不多,但从硝普钠中释放出的氢氰酸却可能在胃肠道吸收,硝普钠口服吸收目杀者表现为与氢氰酸中毒相似的症状;(2)分布:硝普盐可因其与血红蛋白中的巯基接触而加速分解。在小鼠静注[~(14)C]硝普钠后3～5min,血液中的放射活性几集中
Nitrate salt pharmacokinetics: (1) Absorption: Page and other 16 patients with hypertension to oral sodium nitroprusside for 6 weeks to 2 years, 30 ~ 60mg (qid), mild antihypertensive effect appeared only after a few weeks. The blood pressure drop corresponds to the concentration of thiocyanate in the plasma. Sodium nitroprusside absorbed from the gastrointestinal tract is not much, but the release of hydrocyanic acid from sodium nitroprusside may be absorbed in the gastrointestinal tract, sodium nitroprusside oral absorption of those killed showed similar to hydrocyanic acid poisoning Symptoms; (2) Distribution: Nitroprusside accelerates decomposition due to its contact with thiol groups in hemoglobin. In mice intravenous [~ (14) C] sodium nitroprusside 3 ~ 5min, the concentration of radioactivity in the blood of several