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目的研究三阴性乳腺癌的临床病理特征及合理的临床治疗策略。方法对2003年至2007年间我院收治的69例三阴性乳腺癌的临床资料进行回顾性分析。结果三阴性乳腺癌多为绝经前患者,肿瘤直径较大,临床分期较晚,术前化疗的总有效率较高,腋窝淋巴结转移率较低,但p53阳性率较高,内脏转移率较高。结论三阴性乳腺癌以ER(-)、PR(-)和HER-2(-)为特征,对内分泌治疗及Herceptin靶向治疗效果欠佳,临床预后较差,目前尚无针对性的治疗方案。
Objective To study the clinicopathological features and reasonable clinical treatment strategies of triple negative breast cancer. Methods The clinical data of 69 cases of triple negative breast cancer admitted to our hospital from 2003 to 2007 were analyzed retrospectively. The results of triple negative breast cancer are mostly premenopausal patients with large tumor diameter, clinical stage later, the total effective rate of preoperative chemotherapy is higher, lower rate of axillary lymph node metastasis, but a higher positive rate of p53, visceral metastasis rate was higher . Conclusions Triple negative breast cancer is characterized by ER (-), PR (-) and HER-2 (-), which are not effective in endocrine therapy and Herceptin targeted therapy. The clinical prognosis is poor. There is no specific treatment plan .