组织胺在人体由血嗜硷细胞携带至全身,主要存在于肺等器官的浆细胞内(在胃肠道则为非浆细胞)。在创伤、毒素、某些非特异性因子(如化合物48/80)和免疫的刺激下,组织胺即自浆细胞和嗜硷细胞中释出,但经脱氨基和甲基化等代谢作用很快从血浆中消失。Ash和Black分别发现了H_1和H_2受体,抗组织胺可阻断前者的作用,而后者与胃酸的分泌有关。 Histamine is carried throughout the body by blood alkaloids, mainly in the plasma cells of organs such as lungs (non-plasma cells in the gastrointestinal tract). Histamine is released from histamine, ie, plasma cells and basophils, under the influence of trauma, toxins, certain nonspecific agents (eg Compound 48/80) and immunostimulation, but the metabolic effects such as deamination and methylation are rapid Disappear from the plasma Ash and Black found H_1 and H_2 receptors, respectively. Antihistamines blocked the former, whereas the latter was associated with gastric acid secretion.