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目的探讨糖皮质激素对重症肌无力患者外周血B淋巴细胞刺激因子(BAFF)和白介素-6(IL-6)水平的影响。方法 2010年7月至2012年7月期间,我院诊治的30例重症肌无力患者作为观察组研究对象,给予糖皮质激素治疗2个月,观察和比较治疗前后BAFF、IL-6水平,同时以30例正常健康体检者作为正常对照组。结果与对照组相比,观察组外周血IL-6和BAFF水平明显升高,P<0.05,差异有统计学意义;治疗后,观察组患者IL-6和BAFF水平显著降低,P<0.05,差异有统计学意义。结论激素通过抑制IL-6和BAFF水平,调节重症肌无力患者的细胞免疫功能。
Objective To investigate the effects of glucocorticoids on the levels of peripheral blood B-lymphocyte stimulating factor (BAFF) and interleukin-6 (IL-6) in patients with myasthenia gravis. Methods Thirty patients with myasthenia gravis diagnosed and treated in our hospital from July 2010 to July 2012 were enrolled in the study. Patients were treated with glucocorticoid for 2 months. The levels of BAFF and IL-6 before and after treatment were observed and compared. Thirty normal healthy subjects were taken as normal control group. Results Compared with the control group, the levels of IL-6 and BAFF in the peripheral blood of the observation group were significantly increased (P <0.05), and the difference was statistically significant. After treatment, the levels of IL-6 and BAFF in the observation group were significantly decreased (P < The difference was statistically significant. Conclusion Hormone can regulate the cellular immune function in patients with myasthenia gravis by inhibiting the levels of IL-6 and BAFF.