论文部分内容阅读
意大利学者Rzzetto等在1977年用抗HBc阳性病人的血清以直接免疫荧光法检查一名HBsAg阳性的慢性乙型肝炎病人的肝组织,发现肝细胞核内有可与抗HBc发生荧光反应的物质,开始以为是HBcAg,可是经过广泛的电镜检查,未找到HBcAg,用标准抗-HBc血清进行鉴定为阴性。随后研究说明在免疫学上,这种新的物质与HBsAg、HBcAg及HBeAg不同,当时认为它是HBV的第四个抗原系统。按希腊文排列,暂定名为Delta(δ)抗原系
The Italian scholar Rzzetto et al. Examined the liver tissue of a HBsAg-positive chronic hepatitis B patient by direct immunofluorescence with anti-HBc-positive sera in 1977 and found that there was a substance in the nucleus of the hepatocyte that could react with anti-HBc and start Thought it was HBcAg, but after extensive electron microscopy, did not find HBcAg, with the standard anti-HBc serum was identified as negative. Subsequent studies showed that immunologically, the new substance is different from HBsAg, HBcAg and HBeAg, at the time that it is the fourth antigen system of HBV. Arranged in Greek, tentatively named Delta (δ) antigen