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目的:检测凝血因子Ⅶ、Ⅶ、Ⅱ、Ⅰ的活性,研究其在急性心脑血管血栓性疾病中的变化。方法:分别采用凝血活酶时间、部分凝血活酶时间、发色底物法及凝血酶时间法测定了急性心肌梗死(AMI)和急性缺血性脑卒中(AIS)病人血浆FⅦ:C、FⅧ:C、凝血酶原及纤维蛋白原相对活性。结果:AMI病人血浆FⅦ:C为98.3 ％±36.7％,与青年组的104.0％±29.4％和老年组的114.9％±23.6％比较无明显差异(P值均>0.05),而AIS病人为152.9％±30.3％,较青年组和老年组显著升高(P值均<0.001)。AMI病人血浆FⅧ:C为234.2％±57.9％,明显高出青年组的101.2％±32.6％和老年组的116.4％±35.7％(P值均<0.001)。但AIS病人FⅧ:C±为85.5％±32.6％,低于老年组(P<0.05)。AMI和AIS病人血浆凝血酶原活性分别为130.2％±14.7％和128.0％±29.4％,高于青年组的108.0％±7.7％(P<0.001和0.01)和老年组的106.1％±19.4％(P值均<0.001)。AMI和AIS病人血浆纤维蛋白原活性分别为207.2％±53.0％和174.3％±28.5％,二者均显著高于正常青年组的103.3％±11.6％(P值均<0.001)和老年组的143.8％±16.8％(P<0.001和和0.01)。结论:AMI病FⅧ:C增高,AIS病人FⅦ:C增高;二者血浆凝血酶原和纤维蛋白原活性均高于正常水平。
Objective: To detect the activity of coagulation factors Ⅶ, Ⅶ, Ⅱ, Ⅰ and study their changes in acute cardiovascular and cerebrovascular thrombosis. Methods: Plasma FⅦ: C and FⅧ levels in patients with acute myocardial infarction (AMI) and acute ischemic stroke (AIS) were measured by thromboplastin time, partial thromboplastin time, chromogenic substrate method and thrombin time : C, prothrombin and fibrinogen relative activity. Results: The plasma FⅦ: C level in AMI patients was 98.3% ± 36.7%, which was no significant difference compared with 104.0% ± 29.4% in youth group and 114.9% ± 23.6% in elderly group (all P> 0.05), while the AIS patients was 152.9 % ± 30.3%, significantly higher than the young group and the elderly group (P <0.001). In patients with AMI, plasma F Ⅷ: C was 234.2% ± 57.9%, significantly higher than 101.2% ± 32.6% in the youth group and 116.4% ± 35.7% in the elderly group (P <0.001). However, the F Ⅷ: C ± of AIS patients was 85.5% ± 32.6%, lower than that of the elderly group (P <0.05). The plasma prothrombin activities of AMI and AIS patients were 130.2% ± 14.7% and 128.0% ± 29.4%, respectively, higher than 108.0% ± 7.7% (P <0.001 and 0.01) in the young group and 106.1% ± 19.4% P <0.001). The plasma fibrinogen activities in AMI and AIS patients were 207.2% ± 53.0% and 174.3% ± 28.5%, respectively, which were significantly higher than those in normal youth (103.3% ± 11.6%, P <0.001) and 143.8 % ± 16.8% (P <0.001 and 0.01). Conclusion: The FⅧ: C of AMI is higher than that of AIS, and the FⅦ: C is higher in AIS patients. The activity of prothrombin and fibrinogen in both patients are higher than normal.