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140只小鼠,分为单放(~(60)Co 12Gy)、放烧(12Gy+15％体表皮肤Ⅲ度烧伤)和正常对照组。观察小肠上皮畸形细胞的形成及转归。认为小肠隐窝受射线损伤较重的幼稚细胞增殖周期受到严重阻滞,G_1期到G_2期均延长逐渐形成畸形细胞。有的畸形细胞不分裂直到脱落;有的发生流产性增殖;有的则发生病理性核分裂,从而形成形态多样化细胞。难以证实畸形细胞能起到修复肠上皮的作用,但它可能具有一定的吸收、分泌功能,并起到一定的屏障作用。
140 mice were divided into single (~ (60) Co 12Gy), burn (12Gy + 15% body surface third-degree skin burn) and normal control group. To observe the formation and metastasis of small intestinal epithelial cells. It is considered that the proliferation cycle of immature cells injured by radiation is seriously blocked in the small intestine crypts, and the abnormal cells are gradually formed in G_1 phase and G_2 phase. Some deformity cells do not divide until shedding; some abortion occurred proliferation; while others occur pathological mitosis, resulting in morphological diversity of cells. Difficult to confirm abnormal cells can play a role in repair of the intestinal epithelium, but it may have some absorption, secretion, and play a barrier role.