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为验证8号染色体拷贝数目异常的频率随疾病严重程度（按临床分期的进展）而增加这一假说，作者采用其实验室建立的优化程序，对42例乳腺癌样本进行了荧光原位杂交（FISH）。材料为福尔马林固定，石蜡包理的档案标本，在不参阅任何临床信息或其他组织学及病理学结果的情况下，独
To test the hypothesis that the frequency of chromosome 8 copy abnormalities increases with the severity of the disease (according to the progression of the clinical stage), the authors used a laboratory-developed optimization procedure to perform fluorescence in situ hybridization on 42 samples of breast cancer. FISH). The material is formalin-fixed, paraffin-embedded file specimens that are independent of any clinical information or other histological and pathological findings.