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目的分析血管母细胞瘤(HB)临床病理特征。方法回顾性分析47例HB患者HE染色病理特征及SP法染色相关免疫组化标志物表达。结果肿瘤组织表现为特征性间质细胞及其之间丰富的毛细血管,血管壁衬覆扁平内皮细胞。肿瘤组织多阳性表达CD34、CD31、Vim、D2-40、NSE、S100、CD56、EGFR和VEGF,多阴性表达EMA、CK和GFAP。散发性HB患者免疫阳性表达率与VHL相关性HB患者相仿(P>0.05)。结论结合HE染色病理特征及相关标志物表达有助于诊断HB。
Objective To analyze the clinicopathological features of hemangioblastoma (HB). Methods Retrospective analysis of 47 cases of HB pathological features of HE staining and staining SP immunohistochemical markers. Results Tumor tissues showed characteristic stromal cells and abundant capillary vessels and blood vessel wall-covered flat endothelial cells. Tumor tissues mostly expressed CD34, CD31, Vim, D2-40, NSE, S100, CD56, EGFR and VEGF, but negatively expressed EMA, CK and GFAP. Immunohistochemical expression in sporadic HB patients was similar to that in VHL-related HB patients (P> 0.05). Conclusion Combined with the pathological features of HE staining and the expression of related markers contribute to the diagnosis of HB.