心房颤动 (ＡＦ)是最常见的心律失常之一 ,严重时可降低心输出量 ,增加心室灌注压 ,引起血栓栓塞 ,伴室性心率过快时还会加重心力衰竭甚至引起心肌疾病。抗心律失常药常有加速致命性室性心律失常的可能 ,长期服用还有增加死亡的危险。多非利特 (商品名 :ＴｉｋｏｓｙｎＴＭ)是 Atrial fibrillation (AF) is one of the most common arrhythmia, severe cardiac output can be reduced, increased ventricular perfusion pressure, causing thromboembolism, with ventricular heart rate too fast will increase heart failure and even cause heart disease. Antiarrhythmic drugs often accelerate the possibility of fatal ventricular arrhythmias, long-term use and increased risk of death. Dofetilide (trade name: TikosynTM) is