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各种引起慢性肝脏损害的病因理论上均有可能导致肝硬化,但事实上同样的病因长期作用是否最终发生肝硬化在不同个体间有明显的差异。这种差异主要决定于个体的遗传因素和所接触的环境因素。遗传因素相对恒定,可通过分子遗传学技术分析鉴定,为疾病防治提供可靠的实验依据。近年来已有一些肝硬化遗传易感性的报道,本文综述了其中的肝脏解毒酶基因多态性与肝硬化易感性的研究进展,包括GST、MEH、CYP、UGT、NAT等。
A variety of causes of chronic liver damage are theoretically possible to cause cirrhosis, but in fact whether the long-term effects of the same etiology eventually lead to cirrhosis in different individuals were significantly different. This difference depends mainly on the individual’s genetic factors and the environmental factors exposed. Relatively constant genetic factors can be identified by molecular genetic analysis, provide a reliable experimental basis for disease prevention and control. In recent years, some genetic susceptibility to cirrhosis has been reported. This review summarizes the progress of liver detoxification enzyme gene polymorphisms and susceptibility to cirrhosis, including GST, MEH, CYP, UGT, NAT and so on.