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目的探讨卵巢癌99mTc-MIBI显像与化疗疗效的关系及临床意义。方法对28例卵巢癌复发患者进行99mTc-MIBI显像,采集10min及60min两时相的平面像,采用感兴趣区(ROI)技术计算早期和延迟相肿瘤/非肿瘤(T/N)比值及滞留指数(RI);采用TP方案进行化疗,并与T/N、滞留指数进行相关性分析。结果T/N比值及滞留指数低者,对化疗不敏感;T/N比值高、滞留指数高者,化疗有效,差异有统计学意义。结论99mTc-MIBI亲肿瘤显像能预测卵巢癌化疗敏感性,为临床个体化治疗提供理论依据。
Objective To investigate the relationship between 99mTc-MIBI imaging and chemotherapy in ovarian cancer and its clinical significance. Methods Twenty-eight patients with recurrent ovarian cancer underwent 99mTc-MIBI imaging. The planar images of the two phases at 10 and 60 min were collected. The ROI technique was used to calculate the ratio of tumor to non-tumor (T / N) Retention index (RI); the use of TP regimen chemotherapy, and T / N, retention index correlation analysis. Results The lower T / N ratio and retention index were not sensitive to chemotherapy. The higher the T / N ratio, the higher the retention index, the better the chemotherapy, the difference was statistically significant. Conclusion 99mTc-MIBI tumor imaging can predict the chemosensitivity of ovarian cancer and provide a theoretical basis for clinical individualized treatment.