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Clodronate属于双磷酸盐家族,由于能抑制骨吸收,临床上常用于治疗恶性肿瘤骨吸收导致的高钙血症和骨质疏松等,由于其具有高度的水溶性和离子化,clodronate不易穿透生物膜,所以很难从胃肠道吸收,这是所有双磷酸盐的共性。相关文献报道,clodronate的生物活性只有其口服剂量的2. 5％。胃肠道吸收clodronate通常位于胃和部分小肠。如果服药随进餐同时进行,尤其在含有二价阳离子时,主要为钙和铁,则与之很快形成不溶性的络合物。造成吸收更加减少。除了胃肠道对其吸收较低,胃肠道对双磷酸
Clodronate belongs to the family of bisphosphonates. Clodronate is not easy to penetrate the organism due to its high water solubility and ionization due to its ability to inhibit bone resorption, clinically used to treat hypercalcemia and osteoporosis caused by bone resorption of malignant tumors Membrane, so difficult to absorb from the gastrointestinal tract, which is common to all bisphosphonates. 5%. The relevant literature reported that the biological activity of clodronate only 2.5% of its oral dose. Gastrointestinal absorption of clodronate is usually located in the stomach and part of the small intestine. If the medication is taken at the same time as the meal, especially with divalent cations, mainly calcium and iron, an insoluble complex forms with it quickly. Resulting in more reduced absorption. In addition to its lower absorption of the gastrointestinal tract, gastrointestinal pairs of bisphosphonates