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目的 探讨谷胱甘肽S转移酶M 1(GSTM 1)基因多态现象与原发性肝癌遗传易感性的关系。方法 应用多重PCR方法检测 5 4例肝癌患者 (病例组 )和 136例健康人 (对照组 )的GSTM 1空白基因型。结果 病例组GSTM 1空白基因型频率为70 .37% ,对照组则为 45 .5 9% ,两者有非常显著性差异 (P <0 .0 1) ,但 2组均不存在性别、年龄差异 (P均 >0 .0 5 ) ;OR值为 2 .83(95 %CI值为 1.43～ 5 .42 ) ,EF值为 0 .5 3 ,具有GSTM 1空白基因型的个体患肝癌危险性增加 1.83倍。结论 GSTM 1基因多态现象与肝癌遗传易感性有密切的关系 ,提示其空白基因型可作为判断肝癌遗传易感性的指标。
Objective To investigate the relationship between polymorphism of glutathione S transferase M 1 (GSTM 1) gene and genetic susceptibility of primary hepatocellular carcinoma. Methods Multiplex PCR was used to detect GSTM 1 blank genotypes in 54 patients with HCC (case group) and 136 healthy subjects (control group). Results The genotype frequency of GSTM 1 was 70.37% in the case group and 45.5% in the control group. There was a significant difference between the two groups (P < 0.01), but there was no gender or age in the two groups. Differences (P all> 0.05); OR values were 2.83 (95% CI values 1.43 to 5.42), EF values were 0.53, individuals with a GSTM 1 blank genotype had a risk of liver cancer Increased 1.83 times. Conclusion The polymorphism of GSTM 1 gene is closely related to the genetic susceptibility of hepatocellular carcinoma, suggesting that the blank genotype can be used as an index to determine the genetic susceptibility of hepatocellular carcinoma.