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目的探讨乌司他汀治疗急性胰腺炎的临床效果。方法将70例患者随机分为治疗组和对照组各35例,均给予传统治疗。治疗组:乌司他汀20万U加入250 ml溶液中静脉滴注,2次,d,连续7～10 d。对照组:生长抑素250μg/h,经微泵持续静脉泵注,1次/d。连续7～10 d。分别观察两组治疗前后症状、体征以及实验室数据等变化,观察治疗期间的不良反应发生情况。结果治疗组在上腹部不适、腹部压痛等临床症状缓解和血、尿淀粉酶恢复至正常所需时间上均短于对照组,差异有统计学意义(P<0.05);观察组治愈率为28.6%,总有效率94.3%,与对照组治愈率17.1%、总有效率74.2%比较,有显著性差异(P<0.05)。结论乌司他汀治疗急性胰腺炎能有效地缓解临床症状和体征,治疗效果快且好,安全可靠,值得临床进一步推广研究。
Objective To investigate the clinical effect of ulinastatin in the treatment of acute pancreatitis. Methods Seventy patients were randomly divided into treatment group and control group, each of 35 cases were given conventional treatment. Treatment group: Ulinastatin 200 000 U added 250 ml solution intravenous drip, 2 times, d, for 7 to 10 days. Control group: somatostatin 250μg / h, by micro-pump continuous intravenous injection, 1 / d. Continuous 7 ~ 10 d. The changes of symptoms, signs and laboratory data of the two groups before and after treatment were observed, and the incidence of adverse reactions during the treatment period was observed. Results The treatment group was shorter than the control group in relieving clinical symptoms such as abdominal discomfort, abdominal tenderness and the time required for the return of blood and urine amylase to normal, with a significant difference (P <0.05). The cure rate in the observation group was 28.6 %, The total effective rate was 94.3%, which was significantly different from the control group (17.1%) and total effective rate (74.2%) (P <0.05). Conclusion Ulinastatin in the treatment of acute pancreatitis can effectively alleviate the clinical symptoms and signs, the treatment effect is fast and good, safe and reliable, and it is worth further clinical study.