论文部分内容阅读
目的探讨粒细胞集落刺激因子(G-CSF)诱导移植抗白血病效应治疗异基因造血肝细胞移植(allo-HSCT)后复发白血病的疗效及安全性。方法选取2010-01-01-2013-01-31在我院血液科行allo-HSCT后复发白血病患者40例为研究对象,患者给予行粒细胞集落刺激因子动员后,供者外周单个核细胞输注,并逐次增加输注细胞量,间隔1个月输注1次,统计患者临床治疗效果及并发症情况。结果经过治疗后,40例患者再次完全缓解率为62.5%(25/40),未缓解16例;治疗后并发症方面,Ⅰ~Ⅱ度急性、慢性移植物抗宿主病分别为5例、28例。结论复发白血病的治疗上,G-CSF诱导移植抗白血病效应治疗效果理想,不良反应少,值得在临床上推广应用。
Objective To investigate the efficacy and safety of granulocyte-colony stimulating factor (G-CSF) -induced transplantation of leukemia in the treatment of relapsed leukemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods 2010-01-01-2013-01-31 In our hospital blood line allo-HSCT recurrence of leukemia in 40 patients as the research object, patients were given granulocyte colony-stimulating factor mobilization, donor peripheral mononuclear cells Note, and gradually increase the amount of transfused cells, an interval of 1 month infusion 1, statistical treatment of patients with clinical effects and complications. Results After treatment, the complete remission rate was 62.5% (25/40) in 40 patients and 16 patients did not relieve. After treatment, the acute and chronic graft-versus-host disease of grade Ⅰ ~ Ⅱ were 5 and 28 example. Conclusion The treatment of relapsed leukemia, G-CSF induced leukemia effect of transplantation ideal results, fewer adverse reactions, it is worth in the clinical application.