患者,男,43岁,因上腹部胀痛不适伴反酸,纳差,间断黑便一年入院,无呕心、呕吐,腹泻。胃镜检查示:十二指肠球部、降部黏膜见广泛结节样增生,表面光滑,如鹅卵石,边界清晰,腺管规则见图1~图2。病检提示:黏膜组织炎;结肠纤维镜检查:直肠、结肠黏膜未见异常。讨论十二指肠Brunner氏腺增生症属罕见疾病,发病原因不明,多发生于十二指肠球部,也可累及降部,有文献认为是十 Patients, male, 43 years old, due to abdominal pain discomfort with acid reflux, anorexia, intermittent black will be admitted one year, no nausea, vomiting, diarrhea. Gastroscopy showed: duodenal bulb, descending mucosa see extensive nodular hyperplasia, smooth surface, such as pebbles, the boundary is clear, the rules of the duct shown in Figure 1 to Figure 2. Pathological examination tips: mucositis; colonoscopy examination: no abnormalities in the rectum and colon mucosa. Discussion Duodenum Brunner’s gland hyperplasia is a rare disease, the etiology is unknown, occurred in the duodenal bulb, but also involving the descending part, there are documents that are ten