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目的探讨南通市健康人群流行性乙型脑炎(乙脑)抗体水平及其影响因素,评价人群乙脑免疫屏障,为制定乙脑预防控制策略提供依据。方法采用蚀斑减少中和试验对从如皋和海安两个监测点采集的736份血清标本进行乙脑抗体检测。结果乙脑抗体总的阳性率为71.60%,GMT为1∶16.78。如皋市抗体阳性率高于海安县(χ2=11.54,P<0.01),两地区均有随年龄的增加抗体水平增长的趋势。多因素logistic分析发现:免疫史、隐性感染、性别与乙脑抗体阳性有关。结论南通市2岁以上人群乙脑抗体有保护作用,但<1岁的婴儿抗体水平较低,应加强该年龄段人群的保护。
Objective To investigate the level of anti-Japanese encephalitis (JE) antibody in healthy population of Nantong City and its influential factors, evaluate the immune barrier of JE in population, and provide evidence for the prevention and control strategy of JE. Methods A total of 736 serum samples collected from two sites of Rugao and MSC were tested for encephalitis by using plaque reduction neutralization test. Results The positive rate of JE antibody was 71.60% and the GMT was 1:16.78. The positive rate of antibody in Rugao city was higher than that in Haian county (χ2 = 11.54, P <0.01). There was a tendency that antibody level increased with age in both regions. Multivariate logistic analysis found that the history of immunization, latent infection and gender were related to the positive of JE antibody. Conclusions There is a protective effect of JE antibody in people over 2 years old in Nantong City. However, the antibody level in infants younger than 1 year old should be lower, and the protection of this age group should be strengthened.