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目的:对布氏杆菌的临床特点进行探讨。方法:选取某院2014年6月至2015年6月收治的28例布氏杆菌病患者作为研究对象。对所有研究对象进行临床表现、实验室检查、影像学检查、治疗与预后观察和分析。结果:所有患者均出现脑膜炎症状,18例(64.29)表现为脑膜炎,10例(35.71)表现为脑膜脑炎;所有患者经检查,其布氏杆菌血清的凝集试验均表现为阳性;28例患者中,共3例患者影像学检查发现异常;采用多西环素、头孢三嗪、利福平、喹诺酮类、氨基糖苷类、复方磺胺甲基异噁唑其中一种进行治疗,疗程为6-8周;治疗后27例痊愈,1例死亡,治愈率为%96.43%。结论:布氏杆菌病的临床特点比较多样化,脑膜炎最其中最常见的临床表现。神经性布氏杆菌需要与多种疾病进行鉴别,并采用布氏杆菌血清凝集试验进行确诊。进而采用多种抗生素进行长期治疗,具有显著疗效。
Objective: To investigate the clinical features of brucellosis. Methods: Twenty-eight patients with brucellosis admitted to our hospital from June 2014 to June 2015 were selected as the study subjects. The clinical manifestations, laboratory tests, imaging examination, treatment and prognosis of all the subjects were observed and analyzed. Results: All patients had meningitis symptoms. Meningitis was found in 18 patients (64.29) and meningoencephalitis in 10 patients (35.71). All patients tested positive for agglutination test of Brucella serotypes. 28 A total of 3 patients were found to be abnormal in imaging examination. The patients were treated with one of the two drugs, doxycycline, ceftriaxone, rifampicin, quinolones, aminoglycosides and sulfamethoxazole. The course of treatment was 6-8 weeks. After treatment, 27 cases were cured and 1 case died. The cure rate was 96.43%. Conclusions: The clinical features of brucellosis are diverse and meningitis is one of the most common clinical manifestations. Neurogenic brucellosis need to be identified with a variety of diseases, and the use of brucellosis serum agglutination test for diagnosis. Then use a variety of antibiotics for long-term treatment, with a significant effect.