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各种病因的肝脏损伤可引发肝脏的基质降解和基质转换，从而激活肝脏星状细胞，启动肝纤维化过程。纤维化时 Ｔ Ｉ Ｍ Ｐ１ 的合成增加 Ｍ Ｍ Ｐ１ 的合成减少， Ｍ Ｍ Ｐ１ 活性受抑制导致肝纤维化进一步发展。
Various causes of liver damage can lead to liver matrix degradation and matrix conversion, thereby activating the hepatic stellate cells, start the process of liver fibrosis. The synthesis of TI M P1 during fibrosis increases the decrease of the synthesis of M M P1 and the suppression of M M P1 leads to further development of liver fibrosis.