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一些研究发现,溃疡性结肠炎复发期中前列腺素类物质如PGE_2、PGF_(2a)、T_xB_2和PGF_(1a)合成增加,而在缓解期则与正常人无显著差别。这些发现的意义尚不清楚,鉴于血栓素A_2(T_xA_2)和前列环素具有完全相反的作用,有人认为这两种物质的平衡失调具有一定病理意义。目前关于Crohn病中粘膜前列腺素合成尚缺乏资料。为此,作者对Crohn病直肠粘膜的PGE_2、T_xB_2和6-酮PGF1。合成进行了研究。T_xB_2和6-酮PGF_(1a)分别为T_xA_2和前列环素的稳定代谢产物。 17例Crohn病患者,平均年龄40.7岁,其诊断依
Some studies found that the synthesis of prostaglandins such as PGE_2, PGF_ (2a), T_xB_2 and PGF_ (1a) increased during the relapse of ulcerative colitis, while there was no significant difference between the two groups in remission. The significance of these findings is not clear, given the exactly opposite effect of thromboxane A 2 (T_xA_2) and prostacyclin, some people think that the imbalance between these two substances has some pathological significance. There is currently no data on the synthesis of mucosal prostaglandins in Crohn’s disease. To this end, the author of Crohn’s disease rectal mucosa of PGE_2, T_xB_2 and 6-keto PGF1. Synthesis was studied. T_xB_2 and 6-keto PGF_ (1a) are stable metabolites of T_xA_2 and prostacyclin, respectively. 17 cases of Crohn disease, the average age of 40.7 years, according to the diagnosis