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目的 :分析奥曲肽不同给药方式的药理作用及治疗急性胰腺炎的临床效果。方法 :选择2016年5月-2017年2月76例急性胰腺炎患者根据随机数字表分组,各38例。对照组采用奥曲肽间歇静脉输注,微量泵组采用奥曲肽连续静脉输注。比较两组急性胰腺炎治疗效果;起效时间、住院时间、血淀粉酶恢复正常时间、白细胞恢复正常时间;干预前后患者C反应蛋白。结果 :微量泵组急性胰腺炎治疗效果高于对照组,P<0.05;微量泵组起效时间、住院时间、血淀粉酶恢复正常时间、白细胞恢复正常时间短于对照组,P<0.05;干预前两组C反应蛋白相近,P>0.05;干预后微量泵组C反应蛋白优于对照组,P<0.05。结论 :奥曲肽不同连续静脉输注的对急性胰腺炎的临床效果优于间歇静脉输注,可缩短治疗时间,降低C反应蛋白,促使白细胞和血淀粉酶恢复正常。
Objective: To analyze the pharmacological effects of different administration modes of octreotide and the clinical effect of treating acute pancreatitis. Methods: From May 2016 to February 2017, 76 patients with acute pancreatitis were selected according to a random number table and 38 patients in each group. The control group received octreotide intermittent intravenous infusion, and the micropump group received octreotide continuous intravenous infusion. The therapeutic effect of acute pancreatitis was compared between the two groups. The onset time, hospital stay, normal time of serum amylase recovery, normal time of leukocyte recovery, and C-reactive protein in patients before and after intervention were compared. Results: The therapeutic effect of micropump in acute pancreatitis was higher than that in control group (P <0.05). The onset time, hospital stay time, recovery time of serum amylase, leukocyte recovery time were shorter in the micropump group than in the control group (P <0.05) The former two groups of C-reactive protein were similar, P> 0.05; after intervention, C-reactive protein was better than the control group, P <0.05. Conclusion: The clinical effects of different continuous intravenous infusion of octreotide on acute pancreatitis is better than intermittent intravenous infusion, which can shorten the treatment time, reduce the C-reactive protein, and promote normal white blood cells and blood amylase.