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目的探讨急性脑梗死患者神经肽Y与C反应蛋白变化的临床意义。方法检测38例急性脑出血患者(CH组)、36例脑梗死患者(CI组)、35例同期非脑出血非脑梗死住院志愿者(对照组)的血浆神经肽Y及CRP含量。在患者入院当天和发病第4周时进行临床神经功能缺损程度评分(NDS)评定。结果 CI组和CH组血浆NPY和CRP含量明显高于对照组,其差异具有统计学意义(P<0.05);入院时NDS评定属重型患者的血浆NPY和CRP含量高于中型、轻型患者(P<0.05),其差异具有统计学意义;中型患者血浆NPY和CRP含量高于轻型患者(P<0.01),其差异具有统计学意义。血浆NPY和CRP含量异常组患者住院4周时优良率明显低于对照组,其差异具有统计学意义(P<0.05)。结论 CI、CH患者血浆NPY和CRP水平明显升高,病情越重的患者升高越明显,且其预后相对越差。
Objective To investigate the clinical significance of neuropeptide Y and C-reactive protein in patients with acute cerebral infarction. Methods The levels of plasma neuropeptide Y and CRP in 38 patients with acute cerebral hemorrhage (CH group), 36 patients with cerebral infarction (CI group) and 35 hospitalized non-cerebral infarction non-cerebral infarction patients (control group) during the same period were measured. The clinical neurological deficit score (NDS) was assessed on the day of patient admission and at the fourth week of onset. Results The plasma levels of NPY and CRP in CI group and CH group were significantly higher than those in control group (P <0.05). The plasma levels of NPY and CRP in patients with severe NDS at admission were significantly higher than those in moderate and mild type <0.05), and the difference was statistically significant. The plasma levels of NPY and CRP in patients with moderate type were higher than those in patients with mild type (P <0.01), and the difference was statistically significant. The patients with abnormal plasma NPY and CRP levels at 4 weeks of hospitalization were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusions The levels of plasma NPY and CRP in patients with CI and CH were significantly higher. The more severe the patients were, the more obvious the elevation was and the worse the prognosis was.