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目的探讨使用奥硝唑氯化钠静脉滴注液预防口腔颌面部手术后感染的临床效果,为临床治疗提供参考依据。方法回顾性分析2012年1月-2014年1月收治的76例行口腔颌面部手术患者临床资料,根据术后预防感染所使用药物的不同将其分为研究组和对照组,各38例;研究组患者术后给予奥硝唑氧化钠注射液进行治疗,对照组则给予甲硝唑注射液治疗,比较两组患者治疗后有效率,数据采用SPSS 17.0软件进行统计分析。结果研究组治愈21例、显效11例,总有效率为84.21%,对照组治愈11例、显效9例,总有效率为52.63%;治疗前研究组患者检测出厌氧菌42株、对照组检测出46株,治疗后研究组检测出厌氧菌清除率90.48%,对照组检清除率52.17%,两组比较差异均有统计学意义(P<0.05);研究组不良反应有5例、对照组有7例,且两组患者的不良反应均在停药后消失,可见该药的安全性较高。结论奥硝唑氯化钠注射液用于预防口腔颌面部手术后感染效果显著,不仅能够降低术后口腔厌氧菌的感染率,且安全可靠、不良反应少,值得在临床上广泛推广。
Objective To investigate the clinical effect of ornidazole and sodium chloride intravenous drip in preventing postoperative oral and maxillofacial infection and provide reference for clinical treatment. Methods The clinical data of 76 patients undergoing oral and maxillofacial surgery admitted to our hospital from January 2012 to January 2014 were retrospectively analyzed. According to the different drugs used for postoperative infection prevention, they were divided into study group and control group, with 38 cases in each group . Patients in the study group were treated with ornidazole and sodium oxide injection after operation. Metronidazole injection was given to the control group. The treatment efficiency was compared between the two groups. The data were analyzed by SPSS 17.0 software. Results The study group cured 21 cases, markedly effective in 11 cases, the total effective rate was 84.21%, the control group was cured in 11 cases, markedly effective in 9 cases, the total effective rate was 52.63%; 42 cases of anaerobic bacteria in the study group before treatment, control group The detection rate of anaerobic bacteria was 90.48% in the study group and 52.17% in the control group (P <0.05). There were 5 adverse reactions in the study group, The control group had 7 cases, and the adverse reactions in both groups disappeared after stopping the medicine, showing that the drug was safe. Conclusion Ornidazole and sodium chloride injection is effective in preventing oral and maxillofacial infection. It not only can reduce the infection rate of oral anaerobic bacteria, but also is safe and reliable with few adverse reactions. It is worth widely popularizing in clinical practice.