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本文应用生物鉴定法研究吗啡和其拮抗剂纳洛酮对豚鼠离体胆囊肌条的效应,并初步探讨其与已知的植物性神经递质的关系。结果表明,吗啡对豚鼠离体胆囊肌条的自动节律性运动具有明显的加强作用并且有剂量——反应关系。鸦片受体拮抗剂纳洛酮可完全翻转吗啡的加强作用。提示豚鼠胆囊肌条上可能有鸦片受体存在。用阿托品阻断 M 受体后,吗啡的作用明显减弱。因此吗啡对胆囊肌条的加强作用很可能是通过胆碱能神经末梢所释放的递质起作用的。
In this paper, the bioassay was used to study the effect of morphine and its antagonist naloxone on guinea pig gallbladder muscle strips in vitro and its relationship with known plant neurotransmitters. The results showed that morphine significantly enhanced the automatic rhythmic movement of isolated guinea pig muscle strips and had a dose-response relationship. Naloxone, an opiate receptor antagonist, reverses the potentiating effect of morphine. Tip guinea pig gallbladder strips may have opiate receptors exist. With atropine block M receptor, the role of morphine was significantly weakened. Therefore, the strengthening effect of morphine on the gallbladder muscle strips is likely to play a role by the transmitter of cholinergic nerve endings.