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心肌缺血/缺氧通常会导致心脏结构和功能的损伤,黄芩素是广泛分布的一种黄酮类物质,近年研究发现黄芩素能够通过调节细胞信号通路,干预信号通路中关键信号分子的磷酸化过程,对缺血/缺氧心脏发挥保护作用。这些信号通路包括磷脂酰肌醇-3-激酶-丝氨酸/苏氨酸激酶(PI3K/Akt)、丝裂原活化蛋白激酶家族(MAPKs)和核因子-κB(NF-κB)等,及其下游通路蛋白HMGB1、MMP-2/-9、e NOS和凋亡蛋白。现就黄芩素与心肌缺血/缺氧相关信号通路的相互作用机制进行综述。
Myocardial ischemia / hypoxia usually leads to structural and functional damage to the heart. Baicalein is a widely distributed flavonoid. In recent years, baicalein has been shown to interfere with the phosphorylation of key signaling molecules in signaling pathways by regulating cell signaling Process, to protect the ischemic / hypoxic heart. These signaling pathways include phosphatidylinositol 3-kinase-serine / threonine kinases (PI3K / Akt), mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB Pathway proteins HMGB1, MMP-2 / -9, eNOS and apoptotic proteins. Now on the baicalein and myocardial ischemia / hypoxia-related signaling pathways are reviewed.