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目的目的:探讨模拟深埋条件下复合性冲击伤比格犬和大鼠生命耐受力及血气指标的变化规律。方法方法:成年Wistar大鼠344只,比格犬18只,均雌雄各半。血气检测大鼠随机分为对照组、单纯低氧组、缺水缺食组、低氧缺水缺食组、单纯冲击伤组、冲击伤复合缺水缺食组、冲击伤复合低氧缺水缺食组,血气检测时间为第1、3、5、7天,全自动血气分析仪检测动脉血酸碱度(p H)、血氧分压(Pa O2)、二氧化碳分压(Pa CO2);生命耐受大鼠和犬分为4、5、7组,均持续观察至全部死亡。冲击伤模型采用TNT高爆炸药致伤,低氧模型动物均置于10%全自动常压低氧舱内,缺水缺食模型均不予水食供给。结果结果:(1)大鼠单纯冲击伤无死亡,低氧缺水缺食组于10.4~15.8天全部死亡,冲击伤复合低氧缺水缺食组于9.5~15.2天死亡,其中雄性最早死亡时间、最迟死亡时间和平均活存时间均缩短;比格犬单纯冲击伤组无死亡,低氧缺水缺食组于11.9~14.9天死亡,冲击伤复合低氧缺水缺食组10.9~16.7天死亡,雄性死亡发生时间同样早于雌性。(2)动脉血p H值于第1~7天各伤类组均未见明显变化,Pa O2值于所有低氧组皆较未低氧组显著降低,于伤后第1天即明显降低,并呈持续性,尤以冲击伤复合低氧缺水缺食组雄性明显;Pa CO2值于冲击伤复合低氧缺水缺食组明显低于单纯冲击组和冲击伤复合缺水缺食组,冲击伤复合缺水缺食组动物的Pa CO2随观察时间的延长而呈逐渐升高趋势。结论结论:低氧缺水缺食可加重爆炸所致冲击伤伤情,加速死亡,缩短生命耐受时间,雌性的生存能力强于雄性;Pa O2和Pa CO2值降低,具有发生迅速性、高发性、持续性、雄性重于雌性特点。
Objective: To investigate the changes of life tolerance and blood gas index in beagle dogs and rats under complex deep-burial conditions. Methods: There were 344 adult Wistar rats and 18 Beagle dogs, all of which were male and female. Blood gas detection rats were randomly divided into control group, hypoxia group, water deficit group, hypoxia water deficit group, simple impact injury group, impact injury combined lack of water shortage group, impact injury combined with hypoxia In the food-deficient group, blood gas was detected on the 1st, 3rd, 5th and 7th days. The arterial blood gas analyzer (p H), Pa O2 and Pa CO2 were detected by automatic blood gas analyzer. Rats and dogs were divided into 4,5,7 group, were observed until all the deaths. The injury models were injured by TNT high explosive and the animals in hypoxia model were placed in 10% automatic atmospheric hypoxia chamber. Results: (1) The rats were killed only by the impact of the injury, hypoxia lack of water shortage group all died from 10.4 to 15.8 days, the impact of injury hypoxia lack of water scarcity group died in 9.5 to 15.2 days, of which the earliest male death The time, the latest death time and the average survival time were shortened. Beagle dogs without impact on the injured group died from 11.9 to 14.9 days, At 16.7 days of death, males also died earlier than females. (2) There was no significant change of p H in arterial blood on the 1st to 7th day in each injury group. The value of Pa O2 in all hypoxia groups was significantly lower than that in the non-hypoxia group and significantly decreased on the first day , And was persistent, especially in shock-injured hypoxia-deficient group. The PaCO 2 value was significantly lower in shock-injured combined hypoxia-lacking water-deficient group than those in simple-shock group and impingement- The PaCO 2 of the animals in the combination of waterlogging and scarcity rats increased gradually with the prolongation of observation time. Conclusions: Hypoxia lack of water can aggravate the impact of injury caused by the explosion, accelerate death, shorten the life-time tolerance, the viability of females than males; Pa O2 and Pa CO2 values decreased, with the occurrence of rapid, high incidence Sexual, persistent, male over female character.