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目的 :探讨糖尿病视网膜病变患者血清瘦素水平变化规律。方法 :受试对象 12 0例 ,分为对照组 30例 (男 18,女 12 )、糖尿病无视网膜病变组 30例 (男 18,女 12 ) ,非增殖性视网膜病变组 30例 (男 18,女 12 )及增殖性视网膜病变组 30例 (男 18,女 12 ) ,检测血清瘦素、胰岛素、Ⅳ型胶原及血糖浓度 ,分析瘦素水平与其它指标的相关性。结果 :对照组、无视网膜病变组、NPDR组及PDR组血清瘦素浓度分别为 6 91± 1 87μg/L ,7 83± 2 11μg/L ,9 5 6± 2 4 3μg/L和 11 6 9± 2 5 7μg/L ,经协方差分析排除体重指数的影响 ,PDR组血清瘦素浓度高于NPDR组 (t=2 15 ,p<0 0 5 )、无视网膜病变组 (t=2 71,p <0 0 1)及对照组 (t =3 5 0 ,p <0 0 0 1) ;NPDR组高于无视网膜病变组 (t=2 2 3,p <0 0 5 )及对照组 (t=2 75 ,p<0 0 1)。血清瘦素浓度与体重指数、胰岛素呈正相关 (r=0 2 2 ,p <0 0 5 ;r=0 2 8,p<0 0 1)。结论 :糖尿病视网膜病变患者血清瘦素浓度升高 ,且增高的幅度与病情的严重程度正相关
Objective: To investigate the changes of serum leptin level in patients with diabetic retinopathy. Methods: One hundred and twenty subjects were divided into control group (30 males, 18 females), 30 diabetic retinopathy patients (18 males and 12 females), 30 non-proliferative retinopathy patients (18 males, Female 12) and proliferative retinopathy (30 males and 18 females). Serum leptin, insulin, type IV collagen and blood glucose levels were measured. The correlation between leptin levels and other parameters was analyzed. Results: Serum leptin concentrations in control group, non-retinopathy group, NPDR group and PDR group were 6 91 ± 1 87μg / L, 7 83 ± 2 11μg / L, 956 ± 214μg / L and 11 6 9 ± 2 57 μg / L, body mass index was excluded by analysis of covariance. Serum leptin concentration in PDR group was higher than that in NPDR group (t = 21.5, p <0.05), without retinopathy (t = p <0.01) and control group (t = 35O, p <0.01). The NPDR group was higher than that of the non-retinopathy group (t = 2323, p <0.05) = 2 75, p <0 0 1). Serum leptin concentration was positively correlated with body mass index and insulin (r = 0 2 2, p <0 05; r = 0 28, p 0 01). Conclusion: Serum leptin levels in patients with diabetic retinopathy are increased, and the magnitude of the increase is positively correlated with the severity of the disease