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环氧氯丙烷具有升高血糖作用。血糖升高有良好的剂量效应关系和时间效应关系。血糖达峰值后恢复10%,50%,90%的效应与持续时间曲线斜率随剂量增加而递减,提示环氧氯丙烷在体内消除和转运具有多房室模型特性,血糖达峰值持续时间较长。说明环氯氧丙烷升高血糖作用部位在周边室。环氧氯丙烷引起肾上腺皮质束状带细胞光面内质网增多和脂滴增加,髓质肾上腺素细胞分泌颗粒增多和高尔基复合体发达。说明环氧氯丙烷作用于肾上腺皮质束状带细胞,引起糖皮质激素增加,诱导髓质肾上腺素细胞内PNMT增加和活性增强,促使肾上腺素增多,导致血糖升高。
Epichlorohydrin has the effect of raising blood sugar. There is a good dose-effect and time-effect relationship of elevated blood sugar. The peak value of blood glucose recovery 10%, 50%, 90% of the slope of the effect and duration of the curve decreases with dose increase, suggesting that epichlorohydrin in vivo elimination and transport with multi-chamber model characteristics, blood glucose peaks last longer . Description epichlorohydrin elevated blood glucose in the peripheral compartment. Epichlorohydrin causes adrenal fasciculus with increased smooth endoplasmic reticulum and lipid droplets increased medullary adrenal cells increased granules and the development of the Golgi complex. Epichlorohydrin effects on the adrenal fasciculus cells, causing increased glucocorticoid, medullary adrenal cells induced PNMT increased activity and increased to promote increased adrenaline, leading to elevated blood sugar.