患孤独症儿童的社交技能受损，常可因活动过度、易激惹、发脾气和对他人或自身的攻击而加重，放需经典神经阻滞剂和心理及教育方面的综合治疗。神经阻滞剂常能引起锥体外系症状和镇静，在大多数儿童中仅部分有效。本文报告非经典神经阻滞剂氯氮平对3例用氟赈峻醇无效的孤独症儿 Children with autistic disorders have impaired social skills and can often be exacerbated by hyperactivity, irritability, tantrums and attacks on others or themselves, requiring classical neuroleptics and psychotherapy in combination with education. Nerve blockers often cause extra-exacerbation symptoms and sedation, and are only partially effective in most children. This article reports that clozapine, a non-classical nerve blocker, has been shown to be ineffective in 3 children with autism