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为研究鼻Ｔ细胞性淋巴瘤细胞凋亡和增生二者的数量变化及其与该病的临床表现，病理及预后的关系，采用原位末端标记ＤＮＡ片断技术，配合Ｋｉ－６７抗原的表达，对３０例鼻Ｔ细胞性淋巴瘤进行凋亡细胞，增生细胞及细胞分裂像的定量计数观察，并与临床病理表现及生存情况等进行比较和统计学分析。２８例进行了６～２９个月的随访观察，８例死于该病的复发和恶化。结果表明：（１）凋亡细胞与Ｋｉ－６７阳性细胞的数量变化呈明显正相关（Ｐ＜０．０１），与分裂像数及ｂｃｌ－２癌基因蛋白的表达和患者的临床分期等未见明显关系；（２）Ｋｉ－６７阳性细胞数量变化与患者的平均生存时间有明显关系（Ｐ＜０．０２），但凋亡细胞的数量变化及各形态学指标与患者的平均生存时间未见明显关系。还对细胞增生、凋亡、ｂｃｌ－２癌基因蛋白的表达及ＥＢ病毒感染等彼此之间的关系进行了讨论。
In order to study the changes of the number of apoptosis and proliferation of nasal T cell lymphoma and its relationship with the clinical manifestations, pathology and prognosis of the disease, we used in situ end-labeled DNA fragment technology, combined with the expression of Ki-67 antigen, 30 cases of nasal T cell lymphoma apoptosis, proliferation of cells and cell division image quantitative observation, and with clinical and pathological findings and survival were compared and statistical analysis. 28 cases were followed up for 6 to 29 months, 8 patients died of the recurrence and deterioration of the disease. The results showed that: (1) There was a significant positive correlation between the number of apoptotic cells and the number of Ki-67 positive cells (P <0.01), the numbers of mitotic figures and the expression of bcl-2 oncogene protein and the clinical stage (2) There was a significant relationship between the number of Ki-67 positive cells and the mean survival time of patients (P <0.02), but the number of apoptotic cells and the mean survival time of each morphological index were not significantly different See obvious relationship. The relationship between cell proliferation, apoptosis, expression of bcl-2 oncogene protein and Epstein-Barr virus infection was also discussed.