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本文结果显示25例晚期血吸虫病患者中15人抗-LSP阳性(60.0％),其抗-Lsp平均滴度显著高于正常人(P<0.001)。1年后随访证实部分晚血患者之抗-Lsp持续阳性。肝活检确诊为血吸虫病性肝纤维化者9例中,4例抗-Lsp阳性(44.4％);确诊为混合性肝硬化者4例中,3例阳性(75.0％)。进一步证实部分晚期血吸虫病患者体内的确存在针对肝脏的自身免疫反应。
The results of this study showed that 15 out of 25 patients with advanced schistosomiasis had anti-LSP positive (60.0%), and the average anti-Lsp titer was significantly higher than that of normal (P <0.001). Follow-up 1 year later confirmed that some patients with late blood anti-Lsp continued positive. Of the 9 patients diagnosed as schistosomiasis-induced hepatic fibrosis by liver biopsy, 4 were positive for anti-Lsp (44.4%); 3 of the 4 patients diagnosed as mixed cirrhosis were positive (75.0%). Further confirmed that in some patients with advanced schistosomiasis there is indeed an autoimmune response to the liver.