联合网络药理学分析黄芪葛根汤抗阿尔茨海默病治疗作用

来源 :中国药理学与毒理学杂志 | 被引量 : 0次 | 上传用户：wokaoyouyaozhuce

【摘要】

：

目的阿尔茨海默病(AD)是世界第一的神经退行性疾病,目前缺乏有效的治疗药物。研究发现,AD与2型糖尿病(T2DM)之间存在密切联系。课题组系统分析了19种糖尿病治疗复方,从中筛选出具有AD治疗作用的黄芪葛根汤,并通过网络药理学以及现代药理学基础分析探讨黄芪葛根汤治疗AD的潜在靶点及信号通路,阐述其可能的作用机制。方法采用Aβ1-42基因诱导的秀丽隐杆线虫作为AD病理模型,探讨黄芪葛根汤的抗AD作用。从TCMSP和BATMAN-TCM数据库搜索黄芪葛根汤中2味中药的化合物及靶点,使用GeneCards、NC

【作者】

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侯雯倩苏敬刘小凤董劲曲徐兰海洋刘东玲

【机构】

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甘肃中医药大学药学院,甘肃中医药大学科研实验中心

【出处】

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中国药理学与毒理学杂志

【发表日期】

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2021年10期

【关键词】

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黄芪葛根汤阿尔茨海默病网络药理学秀丽隐杆线虫

【基金项目】

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甘肃省高等学校创新基金(2021B-160),甘肃省中医药研究中心开放课题(zyzx-2020-21),甘肃中医药大学科学研究与创新基金(2020KCYB-1)。

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联合网络药理学分析黄芪葛根汤抗阿尔茨海默病治疗作用

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