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目的探讨睾丸卵黄囊瘤的形态结构特点及免疫组化技术在该瘤的诊断及预后中的意义。方法10例睾丸卵黄囊瘤的存档蜡块，经切片、HE染色，分别以AFP、AAT、HCG、CEA、CK、Vimentin行免疫组化S-D法染色。结果HE染色以疏松网状结构、嗜酸性透明小体、S-D小体、腺体及腺样结构为最常见。免疫组化AAT10例均阳性，阳性范围和强度大于AFP。3例CEA阳性病例中，2例死亡，1例失访。HCG均阴性。Vimentin、CK均阳性。结论免疫组化检测该肿瘤的标记蛋白对诊断和预后的判断有一定价值。AAT可作为此瘤的特征性蛋白标记。CEA与肿瘤的预后可能有一定关系。
Objective To investigate the morphological characteristics of testicular yolk sac tumor and the significance of immunohistochemistry in the diagnosis and prognosis of the tumor. Methods 10 cases of testicular yolk sac tumor paraffin blocks were sliced and stained with hematoxylin and eosin and stained with AFP, AAT, HCG, CEA, CK and Vimentin respectively. Results HE staining with loose mesh structure, eosinophilic transparency, S-D body, gland and adenoid structure is the most common. Immunohistochemical AAT10 cases were positive, the positive range and intensity greater than AFP. Of the 3 CEA positive cases, 2 died and 1 lost. HCG were negative. Vimentin, CK were positive. Conclusion Immunohistochemical detection of the tumor marker protein has some value in diagnosis and prognosis. AAT can be used as a characteristic protein marker of this tumor. CEA and the prognosis of cancer may have a certain relationship.