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目的 研究口腔粘膜上皮癌变过程中表皮生长因子受体（ＥＧＦＲ） 的表达及意义。方法 采用免疫组化Ｓ－ Ｐ法对正常口腔粘膜、轻中重度粘膜上皮异常增生和高分化鳞癌共８５ 例标本进行ＥＧＦＲ 检测。结果 正常口腔粘膜全部为阴性。上皮异常增生时，随病变程度加重，ＥＧＦＲ阳性表达也相应提高，至重度异常增生时，阳性表达率达最高峰。而高分化鳞癌时，表达率有所下降。结论 ＥＧＦＲ的表达与口腔鳞癌的发生有关，可作为评估口腔上皮恶变潜能的较好标记物。
Objective To study the expression and significance of epidermal growth factor receptor (EGFR) in the process of carcinogenesis of oral mucosa. Methods Immunohistochemical S-P method for normal oral mucosa, mild to moderate mucosal epithelial dysplasia and well-differentiated squamous cell carcinoma in 85 cases were detected by EGFR. Results All normal oral mucosa was negative. Epithelial dysplasia, with the severity of the disease, EGFR positive expression also increased, to severe dysplasia, the highest positive expression rate. The well-differentiated squamous cell carcinoma, the expression rate decreased. Conclusion The expression of EGFR correlates with the occurrence of oral squamous cell carcinoma and may be a good marker for evaluating the malignant potential of oral epithelium.