微创手术近年来在牙周治疗尤其是牙周再生治疗方面的应用不断发展，其在一定程度上弥补了传统牙周再生治疗的不足。微创手术具有促进伤口愈合、缩短治疗时间、使患者的不适感最小化等优势，治疗效果较传统方法更加明显和肯定。目前国内有关微创拔牙、微创种植等方面的研究较多，但牙周微创手术应用的相关报道却较少，本文通过文献回顾，针对微创手术在治疗牙周骨下袋中的应用、优势、适用范围、所需设备及显微器械，微创手术的龈瓣设计类型，微创手术联合应用生物材料的治疗效果及研究进展进行综述，为临床医师开展牙周微创手术治疗骨下袋提供参考。“,”Minimally invasive surgery develops rapidly in the periodontal treatments, especially in the periodontal regenerative treatment, in recent years. It supplements, to a certain extent, the insufficiency of the conventional periodontal regenerative treatment. The minimally invasive surgery has many advantages such as enhancing the healing process, reducing surgical chair time and minimizing patient discomfort, etc. It has been proved to improve the clinical effect and provide additional benefits compared to conventional approaches. At present, there are many studies on minimally invasive techniques used in tooth extraction or implant placement in China, but there are few reports on the application of periodontal minimally invasive surgical techniques. Thus based on the reviews of the literatures, this article describes the applications, advantages, indications, microsurgical instruments of minimally invasive periodontal surgery on the treatment of intrabony defect, including various minimally invasive surgical procedures. The review also demonstrates the therapeutic effects and research progress of minimally invasive periodontal surgery combined with biomaterials used in the treatments of intrabony defect. The present article may also provide reference for clinicians applying minimally invasive surgeries to treat intrabony defects.