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目的 评价萘丁美酮治疗类风湿关节炎 (RA)的疗效和安全性。方法 12 5例活动性RA患者按随机表法分为两组 ,其中一组患者予以口服萘丁美酮治疗 ,10 0 0mg/d ,共 6 4例 ;另一组患者予以口服双氯芬酸钠 ,75mg/d ,共 6 1例。两组患者的疗程均为 12周。结果 萘丁美酮组的总有效率为 92 31% ,双氯芬酸钠组为 88 5 2 % ,两组比较 χ2 =1 114,P =0 5 73。萘丁美酮组患者红细胞沉降率于治疗前为 38 74mm/ 1h ,治疗后为 2 5 5 6mm/ 1h ,前后比较F =14 0 0 5 ,P <0 0 1;C反应蛋白(CRP)于治疗前为 2 0 8mg/dl,治疗后为 1 2 1mg/dl,前后比较F =6 495 ,P <0 0 5。双氯芬酸钠组红细胞沉降率治疗前为 42 74mm/ 1h ,治疗后 34 36mm/ 1h ,前后比较F =3 811,P >0 0 5 ;CRP于治疗前为 3 2 9mg/dl,治疗后为 2 31mg/dl,前后比较F =2 96 8,P >0 0 5。二种药物引起胃肠道症状的种类与频率相似。治疗后溃疡发生率 :双氯芬酸钠组为 2 70 % (1/ 37) ,而萘丁美酮组为 0。结论 萘丁美酮具有较好的抗炎和止痛作用 ,对活动性指标的改善作用明显优于双氯芬酸钠。对胃粘膜的损伤萘丁美酮明显轻于双氯芬酸钠组
Objective To evaluate the efficacy and safety of nabumetone in the treatment of rheumatoid arthritis (RA). Methods One hundred and twenty-five patients with active RA were divided into two groups according to a randomized table. One group was treated with nabumetone, 100 mg / d, a total of 64 cases; the other group received oral diclofenac sodium, 75 mg / d, a total of 61 cases. Two groups of patients were treated for 12 weeks. Results The total effective rate of nabumetone group was 92 31% and that of diclofenac sodium group was 88 5 2%. The two groups were compared χ2 = 1 114, P = 0 5 73. In the nabumetone group, the erythrocyte sedimentation rate was 3874mm / lh before treatment and was 2565mm / lh after treatment. The anterior and posterior F-14505, P <0.01; C-reactive protein Before treatment, 208 mg / dl, after treatment, 121 mg / dl, before and after comparison F = 6 495, P <0 05. Diclofenac sodium erythrocyte sedimentation rate before treatment was 42 74mm / 1h after treatment 34 36mm / 1h, before and after comparison F = 3811, P> 0.05; CRP before treatment was 299mg / dl, after treatment was 231mg / dl, before and after comparison F = 2 96 8, P> 0 0 5. The two drugs cause gastrointestinal symptoms similar in type and frequency. The incidence of ulcers after treatment was 270% (1/37) in the diclofenac sodium group and 0% in the nabumetone group. Conclusion Nabumetone has a good anti-inflammatory and analgesic effect, and its effect on improving the activity index is better than diclofenac sodium. The damage to gastric mucosa nabumetone was significantly lighter than the diclofenac sodium group