心房利钠多肽(ANP)又称心钠素,是心房产生和分泌的一种生物活性多肽。它的发现揭示了心脏是一个内分泌器官,同时ANP具有很强的利钠,利尿及扩张血管和降低血压的作用。本文利用戊二醛法将ANP与TG连接,免疫家兔,成功地制备抗血清,亲和常数k=0.2-0.3×10~9M~(-1),抗血清与生长抑素、β-内啡肽和K物质等结构类似物的交叉反应百分数分别为3.3％、2.0％和 Atrial natriuretic peptide (ANP), also known as atrial natriuretic peptide, is a bioactive polypeptide produced and secreted by the atria. Its discovery reveals that the heart is an endocrine organ, while ANP has a strong sodium, diuretic and dilation of blood vessels and lower blood pressure. In this paper, ANP was linked to TG by glutaraldehyde method to immunize rabbits and successfully prepared antiserum. The affinity constant k = 0.2-0.3 × 10 ~ 9M -1, antisera and somatostatin, β- The cross-reactivity percentages of structural analogues such as dynorphin and K were 3.3%, 2.0% and