长期血液透析可引起微量元素异常之合并症,如铝、钒过剩与锌缺乏。现引人注目为铝沉着症,可致(1)铝脑病;(2)铝骨病;(3)铝引起1.25(OH)_2D_3作用障碍与(4)PTH分泌抑制等,现主述前三种。 (1)脑病:可致语言障碍、失语、朴翅样肢体抖动、肌阵挛、痴呆与痉挛等致死性脑病,尸检于大脑(尤其是灰白质)有高浓度铝蓄积。 Long-term hemodialysis can cause abnormalities of trace elements such as aluminum, vanadium and zinc deficiency. Already attention is the aluminum disease, can cause (1) aluminum encephalopathy; (2) aluminum bone disease; (3) aluminum caused by 1.25 (OH) _2D_3 and (4) inhibition of PTH secretion is now described in the first three Species. (1) Encephalopathy: can cause speech disorders, aphasia, Park-like limb jitter, myoclonus, dementia and spasticity and other fatal encephalopathy, autopsy in the brain (especially the gray matter) with high concentrations of aluminum accumulation.