用IL-2进行抗肿瘤生长的治疗因其剂量依赖的毒性而受到限制。血液动力的不稳定和急性呼吸衰竭都与血管通透性增加有关。这是继发于微循环内中性白细胞介导的某些活动。而IL-2并不直接作用于中性白细胞。假设IL-2通过诱发产生TNF来介导微血管改变和血液动力的不稳定。 Therapeutic anti-tumor growth with IL-2 is limited by its dose-dependent toxicity. Hemodynamic instability and acute respiratory failure are all associated with increased vascular permeability. This is secondary to some activity mediated by neutrophils inside the microcirculation. IL-2 does not act directly on neutrophils. It is hypothesized that IL-2 mediates microvascular changes and haemodynamic instability by inducing the production of TNF.