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精子正常受血睾屏障所遮蔽,血睾屏障的破坏可导致精子凝集抗体和制动抗体产生。实验动物接种自身精子可发生上述情况;如果精子与弗氏佐剂一起接种,则引起细胞介导免疫应答伴有免疫性睾丸炎和变应性无精子发生。然而,有人对人类不育与上述实验产生的抗精子抗体的关联表示怀疑。如果已发表的著作都能清楚地区别男性的结果与女性的结果(两者可能反映不同的现象,无疑具有不同的临床意义),如果对生育的影响是与精液或宫颈粘液(而不是血
Normal sperm by the blood testis mask obscured, damage to the blood testis barrier can lead to sperm agglutination antibodies and brake antibodies. This can occur with experimental animals vaccinated with their own spermatozoa; if the sperm is inoculated with Freund’s adjuvant it causes a cell-mediated immune response accompanied by immunogenic orchitis and allergic azoospermia. However, there are doubts about the link between infertility and anti-sperm antibodies produced by the above experiments. If a published work clearly distinguishes between male and female results (both of which may undoubtedly have different clinical implications), if the effect on fertility is to be associated with sperm or cervical mucus (rather than blood