糖尿病肾病是终末期肾病的主要病因之一,临床以蛋白尿和肾功能逐渐下降为特点。Kimmelstiel及Wilson首先从组织病理上描述了糖尿病肾病的肾小球系膜基质增加为主要的损伤,而且基底膜增厚曾被认为是重要的病理改变,这些病理改变尤其是系膜基质增生曾认为与蛋白尿形成及肾功能恶 Diabetic nephropathy is one of the major causes of end-stage renal disease, clinical features of proteinuria and renal function decline gradually. Kimmelstiel and Wilson first described histopathologically the increased glomerular mesangial matrix of diabetic nephropathy as the primary lesion, and basement membrane thickening has been considered as an important pathological change that has been identified especially by mesangial matrix proliferation With proteinuria and renal dysfunction