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目的 研究非霍奇金淋巴瘤染色体改变与临床过程及预后的内在联系。方法 采用短期培养法对非霍奇金淋巴瘤进行染色体核型分析,并对全部病人进行临床治疗追踪观察,观察不同核型对治疗的反应。结果 核型正常或t(14;18)改变者效果好,多倍体,1号,7号染色体异常者治疗效果差,据此进行细胞遗传学分型能准确地反映肿瘤的生物学行为。结论 根据特异性染色体改变进行分型,可以对不同病人选择不同的治疗方案,增加治愈率,减少化疗副反应。
Objective To study the relationship between chromosomal changes in non-Hodgkin’s lymphoma and clinical course and prognosis. Methods The genotypes of non-Hodgkin’s lymphoma were analyzed by short-term culture method. All patients were followed up for clinical treatment. The response of different karyotypes to treatment was observed. The results of karyotype or t (14; 18) changes were effective, polyploid, 1, 7, abnormal chromosome aberration treatment is poor, based on which the cytogenetic classification can accurately reflect the biological behavior of the tumor. Conclusion According to the specific chromosomal changes in the classification, different patients can choose different treatment options, increase the cure rate and reduce chemotherapy side effects.