在乙型肝炎病毒(HBV)感染的高发区,HBV 对肝细胞癌的发病有特别重要的作用,但在 HBV 感染的低发区,则肝细胞癌的发病更常与其它因素有关,尤以 HBsAg 阴性的肝硬化病人为然。肝硬化是否由于它本身就是一种癌前状态,抑或肝硬化是否由于其它因素的触发而演变为肝细胞癌,目前对这些问题仍有争议。Gilliam 和 Okuda 等人曾提出非甲非乙型肝炎病毒可作为许多肝硬化病人的一个触发因子。目前已有证据表明许多输血后非甲非乙型慢性肝炎和隐原性慢性肝炎的病人,都含有对抗最近才被鉴定清楚 In the high incidence area of ​​hepatitis B virus (HBV) infection, HBV has a particularly important role in the pathogenesis of hepatocellular carcinoma. However, in the low incidence area of ​​HBV infection, the incidence of hepatocellular carcinoma is more often related to other factors, especially HBsAg-negative patients with cirrhosis. Whether or not cirrhosis is a pre-cancerous condition in itself, or whether cirrhosis has evolved into hepatocellular carcinoma due to triggering of other factors remains controversial. Gilliam and Okuda et al. Have suggested that non-A, non-B hepatitis virus can serve as a trigger for many patients with cirrhosis. At present, there is evidence that many transfusion patients who have non-A, B and Hidden chronic hepatitis have confrontations that have recently been identified