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苯甲酸及其钠盐是常用的防腐剂,具有较强的抗霉菌、抗酵母菌作用。目前广泛使用于液体药剂,特别是中药糖浆剂及其它中药水性浸出制剂。因为这些水性液体药剂含有有利于微生物生长繁殖所需要的物质,所以除严格控制其染菌外,往往需加入一定量的防腐剂。苯甲酸及其钠盐则是有效的防腐剂之一。如复方五味子糖浆、小儿退热合剂、止咳糖浆等均以其作为防腐剂。据不完全统计,新版《药物制剂注解》中糖浆剂、混悬液、胶浆剂、溶液剂、乳膏等剂型中以苯甲酸或苯甲酸钠作防腐剂者就有14种之多。苯甲酸及其钠盐的理化性质早为人所知,日本
Benzoic acid and its sodium salt is a commonly used preservative, with strong anti-mold, anti-yeast effect. Currently widely used in liquid pharmaceuticals, especially Chinese medicine syrup and other traditional Chinese medicine aqueous leaching agents. Because these aqueous liquid medicaments contain substances that are necessary for the growth and reproduction of microorganisms, a certain amount of preservatives are often required besides strictly controlling the bacteria. Benzoic acid and its sodium salt is one of the effective preservatives. Such as compound Schisandra syrup, children antipyretic mixture, cough syrup, etc. are used as a preservative. According to incomplete statistics, there are 14 kinds of dosage forms such as syrup, suspension, glue, solution and cream with benzoic acid or sodium benzoate as preservatives in the new edition of “Pharmaceutical Preparation Notes”. The physicochemical properties of benzoic acid and its sodium salt are well known in Japan