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缺氧诱导因子-1是由α亚基和β亚基组成的一种异源二聚体。在神经细胞缺氧缺血状态下其被诱导表达增加,并通过作用于靶基因的缺氧反应元件调控血管内皮细胞生长因子、葡萄糖载体蛋白-1等靶基因的表达,在缺氧缺血性脑损伤后血管的生成、能量代谢的改善及神经细胞的凋亡中发挥着重要作用。对缺氧诱导因子-1在神经系统中表达及作用的进一步深入探讨,将可能为临床缺氧缺血性脑损伤的治疗提供一种新的途径。
Hypoxia-inducible factor-1 is a heterodimer consisting of the alpha and beta subunits. It is induced to express in hypoxic-ischemic state of nerve cells, and the expression of vascular endothelial growth factor, glucose-loaded carrier protein-1 and other target genes is regulated by hypoxia response elements acting on the target genes. In hypoxic-ischemic After traumatic brain injury, the generation of blood vessels, the improvement of energy metabolism and the apoptosis of nerve cells play an important role. The further study of the expression and role of hypoxia inducible factor-1 in the nervous system may provide a new approach for the treatment of clinical hypoxic-ischemic brain damage.