目的:比较复方甘油和甘露醇治疗急性高血压性脑出血的效果及安全性。方法:160例高血压脑性出血患者随机分为A组60例和B组100例,按病情严重程度分别给予不同剂量复方甘油和甘露醇治疗7-14 d后,比较2组血压、肾功能、副作用及死亡率。结果:A组血压下降不明显,死亡率高,但肾功能损伤较轻;B组血压显著下降,死亡率低,肾功能损伤较重。结论:高血压性脑出血急性期脱水治疗时,应考虑患者的年龄、心肾功能、血压以及病情程度,对于血压较高、中重度脑出血患者建议快速滴注甘露醇,而对于年龄偏大、心肾功能不佳者建议缓慢滴注复方甘油。 Objective: To compare the efficacy and safety of compound glycerol and mannitol in the treatment of acute hypertensive intracerebral hemorrhage. Methods: 160 patients with hypertensive cerebral hemorrhage were randomly divided into group A (60 cases) and group B (100 cases). The patients were given different doses of compound glycerol and mannitol for 7-14 days according to the severity of the illness. The blood pressure, renal function , Side effects and mortality. Results: A group of blood pressure was not significantly decreased, high mortality, but less renal damage; blood pressure decreased significantly in group B, low mortality, severe renal damage. Conclusions: Acute dehydration therapy for hypertensive cerebral hemorrhage should take into account the patient’s age, heart and kidney function, blood pressure and the severity of the disease. For patients with high blood pressure and moderate to severe cerebral hemorrhage, it is recommended to rapidly instil mannitol, while for older patients Heart and kidney dysfunction recommended slow infusion of compound glycerin.