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上海市心血管病研究所和中山医院的有关科研人员,对45只家兔喂以胆固醇、全蛋粉和猪油等高脂饮食使之形成实验性动脉粥样硬化,并选取其中15只家兔的主动脉标本,分别进行了扫描和透射电镜的观察及研究,并与正常家兔作对照。通过扫描电镜观察到主动脉内膜表面有灶性分布的虫蛀状内皮损害,此种内皮损害呈圆或类圆形,边界清楚。还观察到粥样斑块形成的演变过程,在班块形成前,内皮细胞发生灶性变性,萎缩和虫蛀状损害;内皮细胞的另一种变化是增生肿胀,部分细胞肿大呈球形。继而内皮细胞可发生融合,形成条束状或小团块;主动脉内膜表面的小斑块可逐渐增大、变厚、相互融合而成较大的斑块。
Shanghai Institute of Cardiovascular Diseases and Zhongshan Hospital, the researchers, fed 45 rabbits with cholesterol, whole egg powder and lard and other high-fat diet to form experimental atherosclerosis, and select 15 of them Rabbit aorta specimens were scanned and TEM observations and studies, and compared with normal rabbits. Scanning electron microscopy was observed on the surface of the aortic intimal distribution of worm-like endothelial damage, such endothelial damage was round or round, clear boundary. Also observed the evolution of atherosclerotic plaque formation, before the formation of block, endothelial cell focal degeneration, atrophy and worm-eaten lesions; another change in endothelial cells is hyperplastic swelling, some of the cells were spherical. Then the endothelial cells can be fused to form a bundle or small lumps; small plaque on the surface of the aortic intima can be gradually increased, thicker, fused with each other into larger plaques.