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目的：探讨脑损伤后心房钠尿肽（ＡＮＰ），精氨酸加压素（ＡＶＰ）及血管紧张素Ⅱ（ＡｎｇⅡ）与创伤性脑水肿的关系．方法：通过实验性大鼠脑损伤模型，利用放免法检测了脑损伤后１周内血浆ＡＮＰ，ＡＶＰ，ＡｎｇⅡ含量，同时观察脑含水量变化．结果：脑损伤后６～２４ｈ血浆ＡＮＰ减少．４８～７２ｈ明显增多；ＡｎｇⅡ于伤后１周内均明显高于正常和（或）对照组；而ＡＶＰ只于伤后２４ｈ明显高于正常和对照组．伤后７２ｈ内脑含水量明显增多，但于１周后恢复正常．结论：脑损伤后ＡＮＰ，ＡＶＰ，ＡｎｇⅡ的不同变化及相互间的功能平衡失常，可能与脑水肿的发生与发展有关．
Objective: To investigate the relationship between atrial natriuretic peptide (ANP), arginine vasopressin (AVP) and angiotensin Ⅱ (Ang Ⅱ) and traumatic brain edema after brain injury. Methods: The levels of ANP, AVP and AngⅡ in plasma were detected by radioimmunoassay in experimental rat brain injury model. The changes of brain water content were also observed. Results: Plasma ANP decreased 6 ~ 24 h after brain injury. 48h-72h significantly increased; AngⅡin 1 week after injury were significantly higher than the normal and (or) control group; AVP only 24h after injury was significantly higher than the normal and control group. Within 72 hours after injury, the brain water content increased significantly, but returned to normal after 1 week. Conclusion: The different changes of ANP, AVP and AngⅡ and the imbalance of function between them after brain injury may be related to the occurrence and development of cerebral edema.